2013년 미국불임학회(ASRM) P-1101 The more, the better? : the impact of sleep on IVF outcomes. (수면 시간과 시험관 시술의 임신율의 상관 관계)

ILHAE PARK, Doctor1, H.G. Sun1, G.H Jeon2, J.D. Jo3, S.G. Kim1 and K.H. Lee1.
1 Mamapapa & baby OB&GY, 1367-5 Hwashin building 4th floor Dal-dong, Nam-gu Ulsan, Republic of Korea, 680-805; 2Inje University, Haeundae Paik Hospital, Haeundaero 875, Haeundae-Gu Busan, Republic of Korea, 612-030 and 3Ellemedi OB&GY, Dongjeong-dong 540 Changwon, Republic of Korea, 641-490.

OBJECTIVE

The quantity and quality of sleep affects not only health, mood, but also hormones and fertility. Some studies evaluated the impact of sleep on reproductive hormone secretion. However, effect of sleep on IVF outcomes was not well investigated. The purpose of this study is to evaluate the impact of sleep on IVF outcomes.

DESIGN

Retrospective observational study

MATERIALS AND METHODS

This observational study included 656 women undergoing IVF cycles between September 2011 and December 2012. Sleep duration estimations were extracted from the participants’ answers to the questionnaire before starting IVF treatment. The participants were then split into three groups by sleep duration: short-time sleepers (4-6 hours), moderate-time sleepers (7-8 hours) and long-time sleepers (9-11 hours).

RESULTS

The mean sleep duration was 7.4 hours. Among 656 women, 120 women slept usually 4-6 hours per day (short-time sleepers), 445 women, 7-8 hours (moderate-time sleeper), and 91 women, 9-11 hours (long-time sleepers). In each group, age, number of transferred embryos reflected no differences. Number of oocytes (10.6, 10.6, 10.7) and fertilization rate (68%, 68%, 73%) were similar among three groups. Pregnancy rate was significantly higher in the moderate-time sleepers group than in long-time sleepers group [52.6%(234/445) vs. 42.9%(39/91), P=0.045]. Pregnancy rate of the group sleeping moderately had increased tendency as compared with that of the group sleeping shortly [52.6%(234/445) vs. 45.8%(55/120), P=0.090].

CONCLUSION

Getting enough sleep has beneficial effect on reproductive hormone secretion. It might be helpful to fertility and IVF outcomes. However, excessive sleep disturbs circadian rhythms and hormone cycles. Probably by this reason, IVF outcomes could be impaired in our study. Therefore, moderate sleep about 7-8 hours is recommended to the patients undergoing IVF cycles for improving IVF outcomes.